Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

H2ax  H2A.X variant histone   (Synonyms: gammaH2ax, H2afx, H2A.X, Hist5-2ax)
Results	Reference
1	J:282739 Alvarez-Saavedra M, Yan K, De Repentigny Y, Hashem LE, Chaudary N, Sarwar S, Yang D, Ioshikhes I, Kothary R, Hirayama T, Yagi T, Picketts DJ, Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development. Front Mol Neurosci. 2019;12:243
1	J:261973 Bellelli R, Borel V, Logan C, Svendsen J, Cox DE, Nye E, Metcalfe K, O'Connell SM, Stamp G, Flynn HR, Snijders AP, Lassailly F, Jackson A, Boulton SJ, Polepsilon Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis. Mol Cell. 2018 May 17;70(4):707-721.e7
1	J:226657 Callier P, Calvel P, Matevossian A, Makrythanasis P, Bernard P, Kurosaka H, Vannier A, Thauvin-Robinet C, Borel C, Mazaud-Guittot S, Rolland A, Desdoits-Lethimonier C, Guipponi M, Zimmermann C, Stevant I, Kuhne F, Conne B, Santoni F, Lambert S, Huet F, Mugneret F, Jaruzelska J, Faivre L, Wilhelm D, Jegou B, Trainor PA, Resh MD, Antonarakis SE, Nef S, Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling. PLoS Genet. 2014 May;10(5):e1004340
1	J:241332 Chen HR, Juan HC, Wong YH, Tsai JW, Fann MJ, Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex. Cereb Cortex. 2017 Mar 01;27(3):2289-2302
1	J:238877 Chen S, Yao X, Li Y, Saifudeen Z, Bachvarov D, El-Dahr SS, Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium. Development. 2015 Mar 15;142(6):1180-92
1	J:129010 Dirlam A, Spike BT, Macleod KF, Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts. Mol Cell Biol. 2007 Dec;27(24):8713-28
1	J:231503 Gergics P, Brinkmeier ML, Camper SA, Lhx4 deficiency: increased cyclin-dependent kinase inhibitor expression and pituitary hypoplasia. Mol Endocrinol. 2015 Apr;29(4):597-612
1	J:165736 Guerquin MJ, Duquenne C, Lahaye JB, Tourpin S, Habert R, Livera G, New testicular mechanisms involved in the prevention of fetal meiotic initiation in mice. Dev Biol. 2010 Oct 15;346(2):320-30
1*	J:323190 Guo T, Han X, He J, Feng J, Jing J, Janeckova E, Lei J, Ho TV, Xu J, Chai Y, KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis. Elife. 2022 Feb 25;11:e74595
1	J:236382 Hargan-Calvopina J, Taylor S, Cook H, Hu Z, Lee SA, Yen MR, Chiang YS, Chen PY, Clark AT, Stage-Specific Demethylation in Primordial Germ Cells Safeguards against Precocious Differentiation. Dev Cell. 2016 Oct 10;39(1):75-86
1	J:326085 Huang TC, Wang YF, Vazquez-Ferrer E, Theofel I, Requena CE, Hanna CW, Kelsey G, Hajkova P, Sex-specific chromatin remodelling safeguards transcription in germ cells. Nature. 2021 Dec;600(7890):737-742
1	J:316683 Huh MS, Ivanochko D, Hashem LE, Curtin M, Delorme M, Goodall E, Yan K, Picketts DJ, Stalled replication forks within heterochromatin require ATRX for protection. Cell Death Dis. 2016 May 12;7:e2220
1	J:266277 Joseph DB, Chandrashekar AS, Abler LL, Chu LF, Thomson JA, Mendelsohn C, Vezina CM, In vivo replacement of damaged bladder urothelium by Wolffian duct epithelial cells. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8394-8399
1	J:272393 Lavado A, Park JY, Pare J, Finkelstein D, Pan H, Xu B, Fan Y, Kumar RP, Neale G, Kwak YD, McKinnon PJ, Johnson RL, Cao X, The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number. Dev Cell. 2018 Dec 3;47(5):576-591.e8
1	J:211631 Lee Y, Brown EJ, Chang S, McKinnon PJ, Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss. J Neurosci. 2014 Jun 4;34(23):7836-44
1	J:152528 Lee Y, Katyal S, Li Y, El-Khamisy SF, Russell HR, Caldecott KW, McKinnon PJ, The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nat Neurosci. 2009 Aug;12(8):973-80
1	J:333381 Luo Z, Xin D, Liao Y, Berry K, Ogurek S, Zhang F, Zhang L, Zhao C, Rao R, Dong X, Li H, Yu J, Lin Y, Huang G, Xu L, Xin M, Nishinakamura R, Yu J, Kool M, Pfister SM, Roussel MF, Zhou W, Weiss WA, Andreassen P, Lu QR, Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability. Nat Commun. 2023 Feb 10;14(1):762
1	J:336095 Lupan BM, Solecki RA, Musso CM, Alsina FC, Silver DL, The exon junction complex component EIF4A3 is essential for mouse and human cortical progenitor mitosis and neurogenesis. Development. 2023 May 15;150(10)
1	J:305884 Maiani E, Milletti G, Nazio F, Holdgaard SG, Bartkova J, Rizza S, Cianfanelli V, Lorente M, Simoneschi D, Di Marco M, D'Acunzo P, Di Leo L, Rasmussen R, Montagna C, Raciti M, De Stefanis C, Gabicagogeascoa E, Rona G, Salvador N, Pupo E, Merchut-Maya JM, Daniel CJ, Carinci M, Cesarini V, O'sullivan A, Jeong YT, Bordi M, Russo F, Campello S, Gallo A, Filomeni G, Lanzetti L, Sears RC, Hamerlik P, Bartolazzi A, Hynds RE, Pearce DR, Swanton C, Pagano M, Velasco G, Papaleo E, De Zio D, Maya-Mendoza A, Locatelli F, Bartek J, Cecconi F, AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity. Nature. 2021 Apr;592(7856):799-803
1	J:143586 Manuylov NL, Smagulova FO, Leach L, Tevosian SG, Ovarian development in mice requires the GATA4-FOG2 transcription complex. Development. 2008 Nov;135(22):3731-43
1	J:210514 Martinez P, Ferrara-Romeo I, Flores JM, Blasco MA, Essential role for the TRF2 telomere protein in adult skin homeostasis. Aging Cell. 2014 Aug;13(4):656-68
1	J:338931 Matsui Y, Djekidel MN, Lindsay K, Samir P, Connolly N, Wu G, Yang X, Fan Y, Xu B, Peng JC, SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development. Nat Commun. 2023 Aug 8;14(1):4754
1	J:184928 Miles DC, van den Bergen JA, Wakeling SI, Anderson RB, Sinclair AH, Western PS, The proto-oncogene Ret is required for male foetal germ cell survival. Dev Biol. 2012 May 1;365(1):101-9
1	J:151542 Murga M, Bunting S, Montana MF, Soria R, Mulero F, Canamero M, Lee Y, McKinnon PJ, Nussenzweig A, Fernandez-Capetillo O, A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet. 2009 Aug;41(8):891-8
1	J:214297 Myers M, Morgan FH, Liew SH, Zerafa N, Gamage TU, Sarraj M, Cook M, Kapic I, Sutherland A, Scott CL, Strasser A, Findlay JK, Kerr JB, Hutt KJ, PUMA regulates germ cell loss and primordial follicle endowment in mice. Reproduction. 2014 Aug;148(2):211-9
1	J:229930 Nechiporuk T, McGann J, Mullendorff K, Hsieh J, Wurst W, Floss T, Mandel G, The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Elife. 2016;5:e09584
1	J:288307 Ou MY, Ju XC, Cai YJ, Sun XY, Wang JF, Fu XQ, Sun Q, Luo ZG, Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin. Development. 2020 May 15;147(10):dev185132
1	J:339839 Ross JA, Arcos-Villacis N, Battey E, Boogerd C, Orellana CA, Marhuenda E, Swiatlowska P, Hodzic D, Prin F, Mohun T, Catibog N, Tapia O, Gerace L, Iskratsch T, Shah AM, Stroud MJ, Lem2 is essential for cardiac development by maintaining nuclear integrity. Cardiovasc Res. 2023 Sep 5;119(11):2074-2088
1	J:278483 Shi L, Qalieh A, Lam MM, Keil JM, Kwan KY, Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion. Nat Commun. 2019 Jun 13;10(1):2588
1*	J:226703 Shimada M, Dumitrache LC, Russell HR, McKinnon PJ, Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability. EMBO J. 2015 Oct 1;34(19):2465-80
1	J:159625 Silver DL, Watkins-Chow DE, Schreck KC, Pierfelice TJ, Larson DM, Burnetti AJ, Liaw HJ, Myung K, Walsh CA, Gaiano N, Pavan WJ, The exon junction complex component Magoh controls brain size by regulating neural stem cell division. Nat Neurosci. 2010 May;13(5):551-8
1	J:203136 Solomon LA, Russell BA, Watson LA, Beier F, Berube NG, Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly. Hum Mol Genet. 2013 Dec 15;22(24):5015-25
1	J:316135 Su CH, Liao WJ, Ke WC, Yang RB, Tarn WY, The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia. iScience. 2021 Nov 19;24(11):103368
1	J:232924 Vaithiyanathan K, Liew SH, Zerafa N, Gamage T, Cook M, O'Reilly LA, Bouillet P, Scott CL, Strasser A, Findlay JK, Hutt KJ, BCL2-modifying factor promotes germ cell loss during murine oogenesis. Reproduction. 2016 May;151(5):553-62
1	J:310649 Viais R, Farina-Mosquera M, Villamor-Paya M, Watanabe S, Palenzuela L, Lacasa C, Luders J, Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development. Elife. 2021 Aug 24;10:e67989
1	J:165054 Wang WL, Li Q, Xu J, Cvekl A, Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis. Mol Biol Cell. 2010 Jul 15;21(14):2453-68
1	J:277545 Wang Y, Li Q, Liu C, Han F, Chen M, Zhang L, Cui X, Qin Y, Bao S, Gao F, Protein arginine methyltransferase 5 (Prmt5) is required for germ cell survival during mouse embryonic development. Biol Reprod. 2015 Apr;92(4):104
1*	J:198275 Watanabe N, Mii S, Asai N, Asai M, Niimi K, Ushida K, Kato T, Enomoto A, Ishii H, Takahashi M, Murakumo Y, The REV7 subunit of DNA polymerase zeta is essential for primordial germ cell maintenance in the mouse. J Biol Chem. 2013 Apr 12;288(15):10459-71
1	J:201463 Watson LA, Solomon LA, Li JR, Jiang Y, Edwards M, Shin-ya K, Beier F, Berube NG, Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest. 2013 May 1;123(5):2049-63
1	J:170580 Wenzel PL, Chong JL, Saenz-Robles MT, Ferrey A, Hagan JP, Gomez YM, Rajmohan R, Sharma N, Chen HZ, Pipas JM, Robinson ML, Leone G, Cell proliferation in the absence of E2F1-3. Dev Biol. 2011 Mar 1;351(1):35-45
1*	J:311932 White AK, Baumgartner M, Lee MF, Drake KD, Aquino GS, Kanadia RN, Trp53 ablation fails to prevent microcephaly in mouse pallium with impaired minor intron splicing. Development. 2021 Oct 15;148(20):dev199591
1	J:306240 Yamaguchi H, Kitami K, Wu X, He L, Wang J, Wang B, Komatsu Y, Alteration of DNA Damage Response Causes Cleft Palate. Front Physiol. 2021;12:649492
1*	J:87040 Yao HH, DiNapoli L, Capel B, Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads. Development. 2003 Dec;130(24):5895-902
1	J:328457 Yin H, Suye S, Zhou Z, Cai H, Fu C, The reduction of oocytes and disruption of the meiotic prophase I in Fanconi anemia E-deficient mice. Reproduction. 2022 Sep 1;164(3):71-82
1	J:329439 Zhang M, Su L, Wang W, Li C, Liang Q, Ji F, Jiao J, Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development. Cell Rep. 2022 Sep 13;40(11):111350
1	J:266305 Zhou Y, Qin Y, Qin Y, Xu B, Guo T, Ke H, Chen M, Zhang L, Han F, Li Y, Chen M, Behrens A, Wang Y, Xu Z, Chen ZJ, Gao F, Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans. PLoS Genet. 2018 Aug;14(8):e1007463